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In this review, we provide a historical overview of research on Ucns and their receptors in the mammalian endocrine. The potential role of the urocortinergic system is an intriguing topic that deserves further in-depth investigations to develop novel strategies for preventing stress-related conditions and treating endocrine diseases. Urocortins Ucns belong to the corticotropin-releasing hormone CRH family, which includes CRH, fish urotensin I, frog sauvagine, Ucn1, Ucn2 or stresscopin-related peptideand Ucn3 Gay tumblr South Vineland stresscopin [ 1 — 4 ]. This family is a critical regulator of the hypothalamic—pituitary—adrenal HPA axis, leading to subsequent release of adrenocorticotropic hormone and corticosteroids [ 56 ]. These 38—amino acid peptides are structurally related and are highly conserved among different animal species [ 78 ] Fig.

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